Start Time:

8 August 2005 at 08:30

Ends On:

26 August 2005

Location:

Trieste - Italy

Venue:

MB (C)

Organizer(s):

S. Raghu, K.R. Sreenivasan

Description:

Web Page: http://www.ictp.it/~smr1670

BRIEF DESCRIPTION:

This course is an introduction to the flow of fluids in micro/nano-devices with examples chosen from a variety of areas. Although the applications of microfluidics are in a wide range of areas, the fundamental principles of their operation are governed by fluid mechanics: flow in micro/nano channels, mixing and methods of driving such flows. An outline of the course is given below:

1. Introduction
(SR/KRS) Overview of the program and topics, organization of the course (0.5 hr)
KB Historical review: illustrative examples of scientific issues and commercial applications. (1.5 hrs)

2. Fluid Mechanics in Micro/Nano-Scales (KB &AB)
AB 2.1 Fluid Modeling
Continuum Model (and its limits)
Equations of Motion (4 hrs)

KB 2.2 Scaling issues at the microscale
Boundary conditions and liquid-surface interactions
Issues for gases
Issues for liquids
Two-phase flows, interfaces, drops and bubbles (8 hrs)


AB Continuum vs. molecular models
Numerical simulations (continuum and molecular) (4hrs)


AB Pressure driven flows in microchannels Slip Flow regime
Transition and Free-Molecular Regimes

Shear Driven Flows
Slip, Transition and Free Molecular Regimes
Unsteady/Time Periodic Flows (2 hrs)


JM 3. Electrokinetic flow
3.1 Basics of Interfacial Electrokinetics
3.2 Introduction to electrical double layer field and basic electrokinetic
phenomena.
3.3 Electro-osmotic Flows in Microchannels: EO Pumping.
3.4 Electrophoretic flow
3.5 Dielectrophoresis (5 hrs)


HG 4. Typical Microfluidic Applications
Microfluidic systems:
4.1. Microfluidic components:
Actuation principles, microvalves, micropumps, micro-flow sensors, dispensers;
4.2. Micro total analysis systems: principles of integration and interconnection, case studies: ammonia analysis, microdialysis system (2 hrs)

JM 5. Microreactors
Microreactor principles; mixing in microsystems; chaotic advection, heat control in microreactors and micro heat exchangers; examples of gas phase microreactors: partial oxidation, dehydrogenation, microreactors for renewable energy; examples of liquid phase microreactors: organic synthesis on a chip, electrokinetic control of chemistry in a microreactor, electrochemical microreactors. (5 hrs)


HG 6. Spectroscopy on a chip
6.1. Chip-based Nuclear Magnetic Resonance
6.2. Chip-based Mass Spectrometry
6.3. Chip-based Infrared and Raman spectroscopy (4 hrs)


RL 7. Detection on a chip
7.1. Electrical and electrochemical detection
Electrical and electrochemical detection: Conductivity detection, amperometric detection, ISFETs.
7.2. Optical detection
Optical detection: fluorescence, absorption, refractive index, IR, single molecule analysis. (3 hrs)

RL 8. Medical and biological diagnostics on a chip
8.1. Capillary electrophoresis on a chip: Electrokinetic injection, principles of electrophoresis, detection principles, blood analyte measurement examples;
8.2. Sampling: collection, preparation and analysis of biological samples: Microneedle arrays, SPE on a chip
8.3. Micro arrays vs. flow systems, surface vs. bead-based systems; applications
8.4. Cell culturing and monitoring on a chip (5 hrs)

HG 9. Chromatography on a chip
9.1. Gas chromatography
9.2. Liquid chromatography, including entropic traps, field-flow fractionation, hydrodynamic chromatography.DOET. (3 hrs)

SW 10. Experimental Diagnostics for Microfluidics
Measurement of flow quantities such as velocities, temperature and pressure in microfluidics. (10 hrs)

10.1 Introduction, challenges (1 hr)
10.2 Pointwise techniques (1 hr)
10.3 Micro-Particle Image Velocimetry (4 hrs)
10.4 Molecular tagging velocimetry (2 hrs)
10.5 Emerging techniques (2 hr)

SR 11. Design considerations for microfluidic devices
Some design considerations for microfluidic devices such as microcombustors, chem-bio sensors, metabolic monitoring devices and other examples. Micropower generators such as micro fuel cells, microthrusters, microturbines. (5 hrs)
HG 12. Fabrication technologies for microfluidics
Bulk micromachining of silicon (HG)
13.2. Surface micromachining (HG)
13.3. Wafer bonding (HG)
13.4. Glass micromachining (HG)
13.5 Plastic micromaching (RL)
13.6 Other techniques (RL)
13.7 Reliability issues of materials (5 hrs)

EC 13. Nanohydrodynamics (10 hrs)

VS 14. 1. Hydrodynamics of complex fluids in microchannels, limit of hydrodynamic description, elastic turbulence etc.-1 lecture.
14.2. Chaotic mixing in microfluidics-different approaches and various aspects, quantitative characterization of mixing -2 lectures.
14.3. Dynamics of single polymer molecules, vesicles, worm-like micelles in microflows-1-2 lectures.
14.4 Particle suspension and particle trapping, manipulation, size sorting, and size separation by ultrasound in microchannels-1-2 lectures.
14.5. Non-slip-slip boundary conditions -experiments-1 lecture.
14.6. Two-phase flow, bubbles, jets, instabilities in microchannels-1 lecture.

15. Wave propagation in microchannels and micro shock-tubes (?? TBA) ( 1hr)

16. Research topics in microfluidics (TBA)

17. Student presentations (TBA)

Material:

• Programme (PDF )
• announcement
• application_form (deadline for requesting participation: 31 March 2005)
• bulletin